In the present experiment, the effects of acetyl-L-carnitine and L-carnitine on the levels of free, acyl, and total L-carnitine in plasma and brain, rat ambulatory activity, and biomarkers of oxidative stress are investigated. Aged rats (23 months old) were given acetyl-L-carnitine or L-carnitine at 0.15% in drinking water for 4 weeks. L-carnitine and acetyl-L-carnitine were similar in elevating carnitine levels in plasma and brain. Both increased ambulatory activity similarly. However, acetyl-L-carnitine decreased the lipid peroxidation (malondialdehyde, MDA) in the old rat brain, while L-carnitine did not.
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